music, thoughts, books, dreams, more

Just my world of dreams, music and thoughts. Author of two books, one a novel of Love stories set in Framingham, Mass, Secrets of the Heart the 2nd book an autobiography of growing up in Framingham, Mass. Small Town America, Framingham My generation was the first teenage generation, that was when the word was coined. Ours was the generation that started cruising through town and to the drive in theater and drive in restaurant. In our area, Ernie Kampersal,from Holliston, drove his bucking car through town, picking up girls. It rose in the air, like a stallion! We went to the soda shops and played the juke boxes. It was a different town, a different time, and it belonged to us!

Sunday, May 31, 2015

ARTEMISININ SHOWS PROMISE FOR A CANCER DRUG, WITHOUT SIDE EFFECTS

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2005 Oct;9(5):995-1007.

Targeted treatment of cancer with artemisinin and artemisinin-tagged iron-carrying compounds.

Lai H1, Sasaki T, Singh NP.

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Abstract

Artemisinin is a chemical compound that reacts with iron to form free radicals which can kill cells. Cancer cells require and uptake a large amount of iron to proliferate. They are more susceptible to the cytotoxic effect of artemisinin than normal cells. Cancer cells express a large concentration of cell surface transferrin receptors that facilitate uptake of the plasma iron-carrying protein transferrin via endocytosis. By covalently tagging artemisinin to transferrin, artemisinin could be selectively picked up and concentrated by cancer cells. Futhermore, both artemisinin and iron would be transported into the cell in one package. Once an artemisinin-tagged transferrin molecule is endocytosed, iron is released and reacts with artemisinin moieties tagged to transferrin. Formation of free radicals kills the cancer cell. The authors have found that artemisinin-tagged transferrin is highly selective and potent in killing cancer cells. Thus, artemisinin and artemisinin-tagged iron-carrying compounds could be developed into powerful anticancer drugs.